CFP, complement factor properdin, 5199

N. diseases: 108; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.310 Biomarker disease BEFREE YB-1 protein was quantified from IL-1β- or TNFα-stimulated rat hepatoma cells (FaO) and the localization of a YFP-YB-1-CFP fusion protein was visualized by confocal microscopy in HepG2 human hepatocellular carcinoma cells. 22361279 2012
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.010 Biomarker group BEFREE YB-1 protein was quantified from IL-1β- or TNFα-stimulated rat hepatoma cells (FaO) and the localization of a YFP-YB-1-CFP fusion protein was visualized by confocal microscopy in HepG2 human hepatocellular carcinoma cells. 22361279 2012
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.040 Biomarker disease BEFREE While raising many difficult questions, these results suggest that the D2 and D3 receptors in the medial PFC may be an important substrate for cognitive deficits in depression and their remediation. 28567697 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.040 Biomarker disease BEFREE While raising many difficult questions, these results suggest that the D2 and D3 receptors in the medial PFC may be an important substrate for cognitive deficits in depression and their remediation. 28567697 2017
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.040 Biomarker phenotype BEFREE While raising many difficult questions, these results suggest that the D2 and D3 receptors in the medial PFC may be an important substrate for cognitive deficits in depression and their remediation. 28567697 2017
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.060 Biomarker disease BEFREE While raising many difficult questions, these results suggest that the D2 and D3 receptors in the medial PFC may be an important substrate for cognitive deficits in depression and their remediation. 28567697 2017
CUI: C0009241
Disease: Cognition Disorders
Cognition Disorders 		0.050 Biomarker group BEFREE While raising many difficult questions, these results suggest that the D2 and D3 receptors in the medial PFC may be an important substrate for cognitive deficits in depression and their remediation. 28567697 2017
CUI: C4048329
Disease: Immunosuppression
Immunosuppression 		0.010 Biomarker disease BEFREE While CFP-10 and alpha-crystallin are promising candidates for the immunodiagnosis of M. tuberculosis infection or for vaccine use, disease-associated immunosuppression may prevent IFN-gamma immunodiagnosis of more advanced tuberculosis. 14688119 2004
CUI: C1609538
Disease: Latent Tuberculosis
Latent Tuberculosis 		0.050 Biomarker disease BEFREE While CFP-10 and alpha-crystallin are promising candidates for the immunodiagnosis of M. tuberculosis infection or for vaccine use, disease-associated immunosuppression may prevent IFN-gamma immunodiagnosis of more advanced tuberculosis. 14688119 2004
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.100 Biomarker disease BEFREE While CFP-10 and alpha-crystallin are promising candidates for the immunodiagnosis of M. tuberculosis infection or for vaccine use, disease-associated immunosuppression may prevent IFN-gamma immunodiagnosis of more advanced tuberculosis. 14688119 2004
CUI: C1318485
Disease: Liver regeneration disorder
Liver regeneration disorder 		0.020 Biomarker phenotype BEFREE We used transgenic zebrafish, Tg(fabp10a:CFP-NTR), to study the effects of compounds that alter epigenetic factors on BEC-mediated liver regeneration. 30267710 2019
CUI: C0016667
Disease: Fragile X Syndrome
Fragile X Syndrome 		0.010 Biomarker disease BEFREE We show here that FX model mice display substantial deficits in a PFC-dependent task. 28652410 2017
CUI: C0679362
Disease: Tuberculosis, extrapulmonary
Tuberculosis, extrapulmonary 		0.020 Biomarker disease BEFREE We recently detected Mycobacterium tuberculosis lipoarabinomannan (LAM) and CFP-10 (Rv3874) biomarkers from the urinary EVs of pulmonary TB (PTB) and extrapulmonary TB (EPTB) patients by immuno-polymerase chain reaction (I-PCR) assay and the results were compared with the analogous enzyme-linked immunosorbent assay (ELISA). 31549171 2019
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary 		0.090 Biomarker disease BEFREE We recently detected Mycobacterium tuberculosis lipoarabinomannan (LAM) and CFP-10 (Rv3874) biomarkers from the urinary EVs of pulmonary TB (PTB) and extrapulmonary TB (EPTB) patients by immuno-polymerase chain reaction (I-PCR) assay and the results were compared with the analogous enzyme-linked immunosorbent assay (ELISA). 31549171 2019
CUI: C0596344
Disease: clinical anxiety
clinical anxiety 		0.010 Biomarker disease BEFREE We provide preliminary evidence that the link between PFC functioning and anxiety might be attributed to early-emerging temperamental vulnerabilities present before the emergence of clinical anxiety. 26325222 2017
CUI: C0003467
Disease: Anxiety
Anxiety 		0.040 Biomarker disease BEFREE We provide preliminary evidence that the link between PFC functioning and anxiety might be attributed to early-emerging temperamental vulnerabilities present before the emergence of clinical anxiety. 26325222 2017
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		0.040 Biomarker group BEFREE We provide preliminary evidence that the link between PFC functioning and anxiety might be attributed to early-emerging temperamental vulnerabilities present before the emergence of clinical anxiety. 26325222 2017
CUI: C4087273
Disease: C3 glomerulopathy
C3 glomerulopathy 		0.020 GeneticVariation disease BEFREE We previously developed a mouse model of lethal C3 glomerulopathy with factor H and properdin gene double mutations. 28139294 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.090 Biomarker disease BEFREE We further provided evidence that TBP genotypes with greater than 35 CAG repeats, which were enriched in patients with schizophrenia, were significantly associated with hypoactivation of the prefrontal cortex measured by near-infrared spectroscopy during the tower of Hanoi, a task of executive function (right PFC; p = 0.015, left PFC; p = 0.010). 19566714 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.090 GeneticVariation disease BEFREE We found evidence of alterations in the expression of the initial elements of the TLR4 signalling pathway (TLR4, Myeloid differentiation primary response gene 88 [MyD88] and nuclear factor-κ B [NF-κB]) in the PFC of patients with schizophrenia. 27070349 2016
CUI: C0032285
Disease: Pneumonia
Pneumonia 		0.010 Biomarker disease BEFREE We demonstrated that PFD remarkably ameliorated LPS-induced pulmonary inflammation and fibrosis and reduced IL-1β and TGF-β1 levels in bronchoalveolar lavage fluid(BALF). 29783158 2018
CUI: C3714636
Disease: Pneumonitis
Pneumonitis 		0.010 Biomarker disease BEFREE We demonstrated that PFD remarkably ameliorated LPS-induced pulmonary inflammation and fibrosis and reduced IL-1β and TGF-β1 levels in bronchoalveolar lavage fluid(BALF). 29783158 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.010 Biomarker group BEFREE We demonstrate in subsequent experiments that the metal cation transporter CNNM4 regulates growth by induction of apoptosis and identified a tumor suppressive role of complement factor properdin (CFP) in vitro and in vivo. 30755730 2019
CUI: C1609538
Disease: Latent Tuberculosis
Latent Tuberculosis 		0.050 Biomarker disease BEFREE We cultured Peripheral Blood Mononuclear Cells (PBMCs) from HIV- individuals and HIV+ patients with latent tuberculosis and active disease with CFP-10 and ESAT-6. 29996789 2018
CUI: C3854222
Disease: Human immunodeficiency virus (HIV) II infection category B1
Human immunodeficiency virus (HIV) II infection category B1 		0.010 GeneticVariation disease BEFREE We cultured Peripheral Blood Mononuclear Cells (PBMCs) from HIV- individuals and HIV+ patients with latent tuberculosis and active disease with CFP-10 and ESAT-6. 29996789 2018